Safety, tolerability and pharmacokinetics of rilpivirine following administration of a long-acting formulation in healthy volunteers
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چکیده
منابع مشابه
Pharmacokinetics and disposition of rilpivirine (TMC278) nanosuspension as a long-acting injectable antiretroviral formulation.
The next-generation human immunodeficiency virus type 1 (HIV-1) nonnucleoside reverse transcriptase inhibitor rilpivirine (TMC278) was administered in rats and dogs as single intramuscular (IM) or subcutaneous (SC) injections, formulated as a 200-nm nanosuspension. The plasma pharmacokinetics, injection site concentrations, disposition to lymphoid tissues, and tolerability were evaluated in sup...
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ژورنال
عنوان ژورنال: HIV Medicine
سال: 2015
ISSN: 1464-2662
DOI: 10.1111/hiv.12247